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Topical treatment for precancers

Medically reviewed by Mitchell J. Mandel, M.D., F.A.A.D., Board-Certified Dermatologist. Last reviewed .

When you have many precancerous spots, called actinic keratoses, treating one at a time can miss spots that are too small to see yet. Topical, or field, treatment uses a prescription cream across a whole area, such as the face, scalp or forearms.

Common creams

  • Fluorouracil (5-FU), sometimes prescribed with calcipotriene in an off-label combination
  • Imiquimod, which helps the immune system clear damaged cells
  • Tirbanibulin, used for selected actinic keratoses on the face or scalp

What to expect

You apply the prescribed medicine at home for a specific course. Redness, flaking, crusting and soreness can occur, but the reaction and healing time vary by medicine and treatment area. More irritation does not necessarily mean better results. Follow your instructions and contact your provider for severe pain, swelling, open sores or signs of infection.

Where it is offered

Offered at all of our offices.

Q&A

How uncomfortable is it?

The reaction can look worse than it feels, but it can be itchy or sore. Your provider will explain how to care for your skin and when to call us.

Will I need to repeat it?

Many people benefit from repeating treatment every few years, because sun damage keeps producing new spots.

Who performs this treatment

Mitchell J. Mandel

Mitchell J. Mandel, MD, FAAD

Dermatologist, founder · All offices

Bio
Dustin Marks

Dustin Marks, MD, FAAD

Dermatologist · Upper East Side

Emily Tongdee

Emily Tongdee, MD, FAAD

Dermatologist · Downtown Brooklyn

Emma Newman

Emma Newman, PA-C

Physician assistant · Upper East Side

Grace Jarrett

Grace Jarrett, PA-C

Physician assistant · Downtown Brooklyn

Leah Aminov

Leah Aminov, PA-C

Physician assistant · Greenvale

Karen Chen

Karen Chen, PA-C

Physician assistant · Streeterville

Paige Yurick

Paige Yurick, PA-C

Physician assistant · Streeterville

Arielle Ades

Arielle Ades, DNP, FNP-BC

Nurse practitioner · Boulder

Francesca Raedel

Francesca Raedel, FNP-BC

Nurse practitioner · Boulder

Jennifer Telgener

Jennifer Telgener, FNP-BC

Nurse practitioner · Boulder

Christine Sacco

Christine Sacco, FNP-C

Nurse practitioner · Palm Beach Gardens

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Text (516) 212-6116